Repression of Transposable Elements by Histone Biotinylation
نویسندگان
چکیده
منابع مشابه
The Journal of Nutrition Symposium: Nutrients and Epigenetic Regulation of Gene Expression Repression of Transposable Elements by Histone Biotinylation
Transposable elements constitute .40% of the human genome; transposition of these elements increases genome instability and cancer risk. Epigenetic mechanisms are important for transcriptional repression of retrotransposons, thereby preventing transposition events. Binding of biotin to histones, mediated by holocarboxylase synthetase (HCS), is a novel histone mark that plays a role in gene regu...
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Candida albicans is an opportunistic fungal pathogen in humans. It is a polymorphic fungus: it can live as yeasts, hyphae, or pseudohyphae. Biotin is required for cell growth and fatty acid metabolism because it is used as a cofactor for carboxylases such as acetyl-CoA carboxylase, and pyruvate carboxylase. In addition, we have discovered that biotin is used to modify histones in C. albicans. B...
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The ebgA (evolved beta-galactosidase) gene of Escherichia coli was isolated as part of a 9.6-kilobase (kb) sequence cloned into plasmid pBR322. The position of the ebgA gene within that 9.6-kilobase sequence was identified by insertional inactivation by means of the transposon gamma-delta. In addition to the gamma-delta insertions that inactivate ebgA by disrupting the coding sequence, seven ad...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2009
ISSN: 0022-3166,1541-6100
DOI: 10.3945/jn.109.111856